3 / 10
Page 20
Volume 02
Stem Cells 2019 & Pediatrics Congress 2019
November 06-07, 2019
Journal of Clinical Genetics and Genomics
November 06-07, 2019 | Tokyo, Japan
STEM CELLS AND REGENERATIVE MEDICINE
PEDIATRICS AND CHILD CARE
International Conference on
2
nd
World Congress on
&
J Clin Gen Genomics, Volume 02
Mesenchymal stem cells in transplantation: Effect of immunosuppressive drugs
Magdalena Krulova
Charles University, Czech Republic
M
esenchymal stem cells (MSCs) due to their immunosuppressive and regenerative properties offer a great potential for the
application in the clinic, including the transplantation medicine. It was documented that co-transplantation of grafted tissue
with MSCs attenuated rejection reaction. In the therapy of various pathological conditions, applied MSCs interact with different
drugs, which can influence their action. And vice versa, MSCs can modulate the effect of such treatment. Our results demonstrated
that the therapy combining immunosuppressive agents with MSCs favourably influenced immune balance, attenuated the adverse
effects of immunosuppressive drugs and prolonged the survival of transplanted allogeneic cells. Mechanisms involved in the
anti-inflammatory effect of the interactions between MSCs, immunosuppressive drugs and the immune system included switch
in the macrophage phenotype, as well as changes in the subpopulations. As a result, the inflammation was attenuated and a
regenerative environment promoted in the presence of MSCs. We also documented that MSCs isolated from different sources are
differently affected by the immunosuppressive drug treatment. All these findings should be taken into accounts before preparing
strategies combining the use of immunosuppressive drugs and MSCs or the administration of MSCs into an immunosuppressed
organism.
Biography
The aim of research of Krulova is to characterize the molecular and cellular mechanisms of specific immunity which can be consequently
applied in targeted immunoregulation for both the experimental work and the clinical practice. In recent years, her research has focused
on the study of mesenchymal stem cells and Sertoli cells, their characterization, possibilities of differentiation, interaction with cells of
the immune system and their use in transplant medicine.
krulova@natur.cuni.cz