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Volume 2
Journal of Medical Biotechnology
Biotechnology 2018
July 16-17, 2018
World Biotechnology Congress
July 16-17, 2018 Berlin, Germany
Druggability analysis and classification of bacterial histidine kinase
Mohammad Al Sorkhy
Al Ain University of Science and Technology, UAE
A
nti-Microbial Resistance (AMR) is becoming a real threat to humanity with a resistant strains emerging very frequently. The
arising of antibiotics resistance is mainly attributed to the misuse of these agents, in addition to the decline in the development
of new drugs by the pharmaceutical industry. The development of new novel antibiotics is an emerging necessity to counteract this
serious phenomenon. Bacterial Histidine Kinases (HKs) are one of the most promising targets for novel antibacterial drugs. They are
part of the bacterial Two-Component Systems (TCSs), the main signal transduction pathways in bacteria, regulating various processes
including virulence, secretion systems and antibiotic resistance. Since mammalian histidine kinases signal transduction pathway is
different than the prokaryotic one, the inhibition of those pathways could be a potential target for a novel antimicrobial agent. In
this study, the druggability of histidine kinase will be assessed for several bacterial species. In this work, different histidine kinases
of varies bacterial origins were assed. First we performed some extensive data mining in the Protein Data Bank (PDB) to obtain a
large library of crystal structures of histidine kinases, each one of the proteins were then prepared using the Molecular Operating
Environment software (MOE). Druggability assessment of the prepared histidine kinases was then carried out using SiteMap module
of the Schrödinger molecular modeling suite.
Biography
Mohammad Al sorkhy is an assistant professor of cell and computational biology, Dr Al sorkhy started his career as a cell biologist with interest in protein
interactions. Then he started to shift towards computational biology to answer his major question about protein interactions.
sorakhy@gmail.comMohammad Al Sorkhy, J Med Biotechnol 2018, Volume 2