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Volume 3 Journal of Nursing Research and Practice Nursing and Heart 2019
April 22-23, 2019
Nursing Education and Evidence Based Practice Conference
Heart Conference
April 22-23, 2019 Dubai, UAE
World
4th International
&
Curcumin as potential cholesterol-lowering compound in mice fed a high cholesterol diet
Sepide Farahiniya and Masoud salehipoor
Ministry of Education, Iran
Atherosclerosis is the primary pathological process that leads to Cardiovascular Diseases (CVD), and Macrophages are the first
inflammatory cells that linked with atherosclerosis transforming them into foam cells. SR-BI is one of the including genes
involved in cholesterol metabolism. In this study, blood samples were collected, and monocytes were isolated. The effect of curcumin
on the expression of SR-BI in mice with hyperlipidemiya who had received 15 mg / 5ml / Kg curcumin garbage using Real Time
-PCR measuring the serum levels of cholesterol, were analyzed by Analysis of Variance (ANOVA) relationship data each group of
test. The average estimate showed that the expression of SR-BI in the control group to 14.47, in the group (cholesterol) is equal to
12.70, in the group (cur cumin) 12.35 and in the group (Curcumin - cholesterol) 13.22, calculated using statistical software. The level
difference between the expression of SR-BI in the control group and experimental groups (P≤0. 05) does not exist. But to significantly
reduce levels of plasma cholesterol, LDL and TG in the experimental group were fed with curcumin and increase HDL. It seems that
curcumin has a unique effect on lipid metabolism and can be effected on prevention of atherosclerosis.
Biography
Sepideh Farahiniya currently works as a Teacher at Ministry of Health, Iran. She has completed her MasterDegree and research interests include Immunology,
Microbiology, Molecular Biology, Pathology, Pharmacology, Physiology, Anatomy, Biochemistry, Biology, Biotech, Ecology, Genetics, Genomics, Health Sciences,
Zoology. Her publications include: Curcumin as potential cholesterol-lowering compound in mice fed a high cholesterol diet; The effect of curcumin on NAFLD;
Compilation of the book in 6 volumes; Translation of MicroRNAs: Key Regulators of Oncogenesis.
Sepide Farahiniya et al., J Nursing Research and Practice, Volume 3
DOI: 10.4172/2632-251X-C3-008